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Literature summary extracted from

  • Saito, M.; Takano, T.; Nishimura, T.; Kohara, M.; Tsukiyama-Kohara, K.
    3beta-hydroxysterol DELTA24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy (2015), PLoS ONE, 10, e0124197 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.3.1.72 medicine surface DHCR24 can be a valuable target for hepatitis C virus-related hepatocellular carcinoma therapy, and 2-152a MAb appears to be useful for this targeted therapy Homo sapiens
1.3.1.72 pharmacology 3beta-hydroxysterol DELTA24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.72 additional information construction of a specific chimeric antibody 2-152a MAb Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.72 cell surface hepatocellular carcinoma cells, hepatoblastoma cell line, and cervical adenocarcinoma-derived cell line Homo sapiens 9986
-
1.3.1.72 endoplasmic reticulum membrane primarily, a putative transmembrane domain exists in the N-terminus of DHCR24 Homo sapiens 5789
-
1.3.1.72 additional information no DHCR24 expression on the surface of the normal human hepatocyte lines NKNT and TTNT Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.72 Homo sapiens Q15392
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.72 HeLa cell
-
 Homo sapiens
-
1.3.1.72 HEP-3B cell
-
 Homo sapiens
-
1.3.1.72 Hep-G2 cell
-
 Homo sapiens
-
1.3.1.72 hepatocellular carcinoma cell DHCR24 is specifically expressed on the surface of HCC cell lines Homo sapiens
-
1.3.1.72 Huh-7 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.72 3beta-hydroxysterol DELTA24-reductase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.1.72 Homo sapiens DHCR24 is overexpressed in hepatitis C virus-related hepatocellular carcinoma specifically induced by hepatitis C virus up

General Information

EC Number General Information Comment Organism
1.3.1.72 malfunction 2-152a MAb-mediated binding of a cytotoxic agent (a saponin-conjugated secondary antibody) to surface DHCR24 leads to significant cytotoxicity. HCV replication can be suppressed by inhibiting DHCR24 with an enzymatic inhibitor Homo sapiens
1.3.1.72 physiological function surface DHCR24 on hepatocellular carcinoma cells can function as a carrier for internalization, e.g. of hepatitis C virus, HCV. DHCR24-mediated cholesterol biosynthesis plays a crucial role in the HCV life cycle. Antibody 2-152a MAb-mediated binding of 2ndAb-Sap to surface DHCR24 on hepatocellular carcinoma cells predicted to lead to internalization of 2ndAb-Sap and subsequent cell death Homo sapiens